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STCS Output Data
27.06.2017 STCS Output Data Download
STCS Reports
13.11.2013 Annual report 2013 Download
25.11.2015 Annual report 2014 Download
05.09.2016 Annual report 2015 Download
27.06.2017 Annual report 2016 Download
Scientific Publications
2017 BK Polyomavirus-Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study.
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Leboeuf, C., et al.
Journal
American journal of transplantation
URL
no url provided
2017 Employment 12 months after kidney transplantation: An in-depth bio-psycho-social analysis of the Swiss Transplant Cohort
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Danuser, B., et al.
Journal
Plos one
2017 Evolution of body weight parameters up to 3 years after solid organ transplantation: The prospective Swiss Transplant Cohort Study.
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Beckmann, S., et al.
Journal
Clinical transplantation
URL
no url provided
2017 ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study.
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Mauthner, O., et al.
Journal
Journal of advanced nursing
URL
no url provided
2017 Human MicroRNA Responses Predict Cytomegalovirus Replication Following Solid Organ Transplantation
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Han, S.H., et al.
Journal
The journal of infectious diseases
URL
no url provided
2017 Outcome and treatment of nocardiosis after solid organ transplantation: new insights from a European study
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Lebeaux, D., et al.
Journal
Clinical infectious diseases
URL
no url provided
2017 Rapid adaptation drives invasion of airway donor microbiota by Pseudomonas after lung transplantation
Abstract
no abstract provided
Year
2017
Type
Report
Authors
M. Beaume,1 T. Köhler,1 G. Greub,2,3 O. Manuel,3,4 J-D. Aubert,4,5 L. Baerlocher,6 L. Farinelli,6 A. Buckling,7 C. van Delden,a,1 and The Swiss Transplant Cohort Study
Journal
Scientific reports
URL
no url provided
2017 Rapid adaptation drives invasion of airway donor microbiota by Pseudomonas after lung transplantation.
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Beaume, M., et al.
Journal
Scientific reports
2017 Torque Teno Virus Load and Acute Rejection after Orthotopic Liver Transplantation.
Abstract
no abstract provided
Year
2017
Type
Article
Authors
Simonetta, F., et al.
Journal
Transplantation
URL
no url provided
2016 HIV-Positive-to-HIV-Positive Liver Transplantation
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Calmy, A., et al.
Journal
American journal of transplantation
URL
no url provided
2016 Adrenergic Receptor Polymorphism and Maximal Exercise Capacity after Orthotopic Heart Transplantation
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Mélanie Métrich, Fortesa Mehmeti, Helene Feliciano, David Martin, Julien Regamey, Piergiorgio Tozzi, Philippe Meyer, Roger Hullin, et al.
Journal
Plos one
2016 Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Eric Bernasconi, Céline Pattaroni, Angela Koutsokera, Christophe Pison, Romain Kessler, Christian Benden, Paola M Soccal, Antoine Magnan, John-David Aubert, Benjamin J Marsland, et al.
Journal
American journal of respiratory and critical care medicine
URL
no url provided
2016 Chronic Lung Allograft Dysfunction: A Systematic Review of Mechanisms.
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Royer, P.J., et al.
Journal
Transplantation
2016 Clinical Presentation and Determinants of Mortality of Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: A Multinational Cohort Study.
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Francisco Lopez-Medrano, Mario Fernandez-Ruiz, José Tiago Silva, Peggy L Carver, C Delden, Esperanza Merino, Maria José Pérez-Saez, Milagros Montero, Julien Coussement, M Abreu Mazzolin, et al.
Journal
Journal of transplantation
URL
no url provided
2016 Exploring frailty and mild cognitive impairment in kidney transplantation to predict biomedical, psychosocial and health cost outcomes (GERAS): protocol of a nationwide prospective cohort study
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Oliver Mauthner, Veerle Claes, Jeremy Walston, Sandra Engberg, Isabelle Binet, Michael Dickenmann, Déla Golshayan, Karine Hadaya, Uyen Huynh- Do, Stefano Calciolari, et al.
Journal
Journal of advanced nursing
URL
no url provided
2016 Human Cytomegalovirus Infection Enhances NK Cell Activity In Vitro
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Astrid Tschan-Plessl, Martin Stern, Laurent Schmied, Christelle Retière, Hans H Hirsch, Christian Garzoni, Christian van Delden, Katia Boggian, Nicolas J Mueller, Christoph Berger, et al.
Journal
Transplantation direct
2016 Microbial Communities of Conducting and Respiratory Zones of Lung-Transplanted Patients
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Marie Beaume, Vladimir Lazarevic, Thilo Köhler, Nadia Gaia, Oriol Manuel, John-David Aubert, Loic Baerlocher, Laurent Farinelli, Paola Gasche, Jacques Schrenzel, et al.
Journal
Frontiers in microbiology
2016 Mortality Prediction after the First Year of Kidney Transplantation: An Observational Study on Two European Cohorts.
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Lorent, M., et al.
Journal
Plos one
2016 Nocardia Infection in Solid Organ Transplant Recipients: A Multicenter European Case-control Study.
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Julien Coussement, David Lebeaux, Christian van Delden, Hélène Guillot, Romain Freund, Sierk Marbus, Giovanna Melica, Eric Van Wijngaerden, Benoit Douvry, Steven Van Laecke, et al.
Journal
Clinical infectious diseases
URL
no url provided
2016 Polymorphisms in the lectin pathway of complement activation in uence the incidence of acute rejection and graft outcome after kidney transplantation
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Déla Golshayan, Agnieszka Wojtowicz, Stéphanie Bibert, Nitisha Pyndiah, Oriol Manuel, Isabelle Binet, Leo H Buhler, Uyen Huynh-Do, Thomas Mueller, Jürg Steiger, et al.
Journal
Kidney international
URL
no url provided
2016 Preventive Strategies Against Cytomegalovirus and Incidence of alpha-Herpesvirus Infections in Solid Organ Transplant Recipients: A Nationwide Cohort Study.
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Martin-Gandul, C., et al.
Journal
American journal of tranplantation
URL
no url provided
2016 Risk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Study.
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Francisco Lopez-Medrano, José Tiago Silva, Mario Fernandez-Ruiz, Peggy L Carver, Christian Delden, Esperanza Merino, Maria José Pérez- Saez, Milagros Montero, Julien Coussement, Milene Abreu Mazzolin, et al.
Journal
American journal of transplantation
URL
no url provided
2016 Ventricular assist devices as bridge to heart transplantation: impact on post-transplant infections
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Delphine Héquet, Georg Kralidis, Thierry Carrel, Alexia Cusini, Christian Garzoni, Roger Hullin, Pascal R Meylan, Paul Mohacsi, Nicolas J Mueller, Frank Ruschitzka, et al.
Journal
Bmc infectious diseases
2016 Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations
Abstract
no abstract provided
Year
2016
Type
Article
Authors
Nuria Saigi-Morgui, Lina Quteineh, Pierre-Yves Bochud, Severine Crettol, Zoltan Kutalik, Agnieszka Wojtowicz, Stéphanie Bibert, Sonja Beckmann, Nicolas J Mueller, Isabelle Binet, et al.
Journal
Plos one
2015 A multi-omics data integration approach to identify a predictive molecular signature of CLAD
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Johann Pellet, Diane Lefaudeux, Pierre-Joseph Royer, Angela Koutsokera, Sandrine Bourgoin-Voillard, Markus Schmitt, Candice Trocme, Johanna Claustre, Andreas Fritz, Michel Seve, et al.
Journal
European respiratory journal
URL
no url provided
2015 A significant effect of the killer cell immunoglobulin-like receptor ligand human leucocyte antigen-C on fibrosis progression in chronic C hepatitis with or without liver transplantation
Abstract
no abstract provided
Year
2015
Type
Article
Authors
S Buhler, E Giostra, C Gbame, C de Rham, B Mullhaupt, JF Dufour, P Majno, F Negro, PY Bochud, and J Villard
Journal
Liver international: offcial journal of the international association for the study of the liver,
URL
no url provided
2015 Co-40: Prevalence of hypertension and uncontrolled hypertension in the swiss transplant cohort study 6 and 12 months after solid organ transplantation
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Y Lu, D Golshayan, P Marques-Vidal, M Pascual, M Burnier, G Wuerzner, et al.
Journal
Annales de cardiologie et d'angeiologie
URL
no url provided
2015 CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation.
Abstract
no abstract provided
Year
2015
Type
Article
Authors
L Quteineh, PY Bochud, D Golshayan, S Crettol, JP Venetz, O Manuel, Z Kutalik, A Treyer, R Lehmann, NJ Mueller, et al.
Journal
The pharmacogenomics journal
URL
no url provided
2015 IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Agnieszka Wójtowicz, Mark S Gresnigt, Thanh Lecompte, Stephanie Bibert, Oriol Manuel, Leo AB Joosten, Sina Rueger, Christoph Berger, Katia Boggian, Alexia Cusini, et al.
Journal
Journal of infectious diseases
2015 Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes.
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Laurent Schmied, Grzegorz Terszowski, Asensio Gonzalez, Karin Schmitter, Hans H Hirsch, Christian Garzoni, Christian van Delden, Katia Boggian, Nicolas J Mueller, Christoph Berger, et al.
Journal
Transplantation
2015 PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Wojtowicz, A., et al.
Journal
Clinical infectious diseases
2015 Reply to Cunha et al.
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Wojtowicz, A., et al.
Journal
Clinical infectious diseases
URL
no url provided
2015 Risk Stratification for Rejection and Infection after Kidney Transplantation
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Pietro E Cippà, Marc Schiesser, Henrik Ekberg, Teun van Gelder, Nicolas J Mueller, Claude A Cao, Thomas Fehr, and Corrado Bernasconi
Journal
Clinical journal of the american society of nephrology
URL
no url provided
2015 The impact of infection on chronic allograft dysfunction and allograft survival after solid organ transplantation
Abstract
no abstract provided
Year
2015
Type
Article
Authors
C Martin-Gandul, NJ Mueller, M Pascual, and O Manuel
Journal
American journal of transplantation
URL
no url provided
2015 The swiss transplant cohort study: lessons from the first 6 years
Abstract
no abstract provided
Year
2015
Type
Article
Authors
Christoph Berger, Pierre-Yves Bochud, Katja Boggian, Alexia Cusini, Adrian Egli, Christian Garzoni, Hans H Hirsch, Matthias Hoffmann, Nina Khanna, Oriol Manuel, et al.
Journal
Current infectious disease reports
URL
no url provided
2014 Cytomegalovirus serology and replication remain associated with solid organ graft rejection and graft loss in the era of prophylactic treatment.
Abstract
no abstract provided
Year
2014
Type
Article
Authors
Martin Stern, Hans Hirsch, Alexia Cusini, Christian Van Delden, Oriol Manuel, Pascal Meylan, Katia Boggian, Nicolas J Mueller, Michael Dickenmann, et al.
Journal
Transplantation
2014 Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication nonadherence as risk factor for post-transplant nonadherence to immunosuppressives: the Swiss Transplant Cohort Study
Abstract
no abstract provided
Year
2014
Type
Article
Authors
Sabina De Geest, Hanna Burkhalter, Laura Bogert, Lut Berben, Tracy R Glass, and Kris Denhaerynck.
Journal
Transplant international
2014 Enterococcal infection in kidney transplant recipients in a setting of low prevalence of vancomycin resistance
Abstract
no abstract provided
Year
2014
Type
Article
Authors
M Fernandez-Ruiz, F Lopez-Medrano, A Andrés, JM Morales, and JM Aguado.
Journal
Transplant infectious disease
URL
no url provided
2014 Impact of enterococcal colonization and infection in solid organ transplantation recipients from the Swiss Transplant Cohort Study
Abstract
no abstract provided
Year
2014
Type
Article
Authors
Bucheli E, Kralidis G, Boggian K, Cusini A, Garzoni C, Manuel O, Meylan PR, Mueller NJ, Khanna N, van Delden C, Berger C, Koller MT, Weisser M; Swiss Transplant Cohort Study.
Journal
Transplant infectious disease
URL
no url provided
2014 Influence of IFNL3/4 Polymorphisms on the Incidence of Cytomegalovirus Infection After Solid-Organ Transplantation
Abstract
no abstract provided
Year
2014
Type
Article
Authors
Oriol Manuel, Agnieszka Wójtowicz, Stéphanie Bibert, Nicolas J. Mueller, Christian van Delden, Hans H. Hirsch, Juerg Steiger, Martin Stern, Adrian Egli,Christian Garzoni, Isabelle Binet, Maja Weisser, Christoph Berger, Alexia Cusini, Pascal Meylan, Manuel Pascual, Pierre-Yves Bochud, and the Swiss Transplant Cohort Study (STCS)
Journal
Journal of infectious diseases
2014 KIR-associated protection from CMV replication requires pre-existing immunity: a prospective study in solid organ transplant recipients
Abstract
no abstract provided
Year
2014
Type
Article
Authors
A Gonzalez, K Schmitter, HH Hirsch, Christian Garzoni, Christian Van Delden, K Boggian, NJ Mueller, Christoph Berger, Jean Villard, O Manuel, et al.
Journal
Genes and immunity
URL
no url provided
2014 Mass spectrometry methods for biomarker research for chronic lung allograft dysfunction (CLAD) in systems prediction of CLAD (SysCLAD)
Abstract
no abstract provided
Year
2014
Type
Article
Authors
Johanna Claustre, Sébastien Quétant, Candice Trocmé, Sandrine Bourgoin-Voillard, Hélène Flamant-Waret, Izabel Bérard, Bertrand Toussaint, Karine Botturi-Cavaillès, Antoine Magnan, Laurent Nicod, et al.
Journal
European respiratory journal
URL
no url provided
2014 Prediction of chronic lung allograft dysfunction: a systems medicine challenge.
Abstract
no abstract provided
Year
2014
Type
Article
Authors
Pison, C., et al.
Journal
European respiratory journal
2013 Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non-adherence: a cross-sectional, multi-center study.
Abstract
no abstract provided
Year
2013
Type
Article
Authors
Burkhalter, H., et al.
Journal
Clinical transplantation
URL
no url provided
2013 Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort
Abstract
no abstract provided
Year
2013
Type
Article
Authors
Michael T. Koller • Christian van Delden • Nicolas J. Müller • Philippe Baumann • Christian Lovis • Hans-Peter Marti • Thomas Fehr • Isabelle Binet • Sabina De Geest • Heiner C. Bucher • Pascal Meylan • Manuel Pascual • Jürg Steiger
Journal
european journal of epidemiology european journal of epidemiology
2013 Impact of antiviral preventive strategies on the incidence and outcomes of cytomegalovirus disease in solid organ transplant recipients.
Abstract
no abstract provided
Year
2013
Type
Article
Authors
O Manuel, G Kralidis, NJ Mueller, HH Hirsch, Christian Garzoni, Christian Van Delden, Christoph Berger, K Boggian, A Cusini, MT Koller, et al.
Journal
American journal of transplantation
2013 The Swiss Transplant Cohort Studys framework for assessing lifelong psychosocial factors in solid-organ transplants
Abstract

Background
Understanding outcomes after transplant requires a biopsychosocial model that includes biomedical and psychosocial factors. The latter, to date, are assessed only in a limited way as part of transplant registries or cohort studies.

The Swiss Transplant Cohort Study (STCS) is a nationwide open cohort study (starting May 2008) to systematically and prospectively assess psychosocial factors. This article describes the framework underpinning STCSs psychosocial assessment.

Methods
The STCS framework was adapted from the multidimensional conceptual perspective of Dew et al to describe transplant psychosocial domains and specific outcomes by adding a time perspective, a system perspective, and interaction among domains.

Results
We propose a multidimensional, multilevel biopsychosocial framework representing mutually influencing domains from before to after transplant, and exemplify each domain by factors included in STCS and their measurement. The transplant patient, centrally positioned, is described by clinical and sociodemographic characteristics (eg, socioeconomic status, educational, professional, and relationship status).

The following psychosocial domains further describe the patient: (1) physical/functional (eg, perceived health status, sleep quality, daytime sleepiness), (2) psychological (eg, depression, stress), (3) behavioral (eg, medication adherence, smoking, drug use, physical activity, sun protection), (4) social (eg, work capacity/return to work), and (5) global quality of life.

Factors associated with health care system level (eg, trust in transplant team) are also included in the model. Conclusion The STCSs psychosocial framework provides a basis for studying the interplay of biomedical, sociodemographic, psychosocial, behavioral, and health care system factors in view of transplant outcomes and therefore has the potential to guide biopsychosocial transplant research. (Progress in Transplantation. 2013; 23:xxx-xxx)

Year
2013
Type
Article
Authors
De Geest S. et al.
Journal
Progress in transplantation, vol 23, no. 3, september 2013
URL
no url provided
2013 Validation of a single item to assess daytime sleepiness for the Swiss Transplant Cohort Study
Abstract

Context Daytime sleepiness in kidney transplant recipients has emerged as a potential predictor of impaired adherence to the immunosuppressive medication regimen. Thus there is a need to assess daytime sleepiness in clinical practice and transplant registries. Objective To evaluate the validity of a single-item measure of daytime sleepiness integrated in the Swiss Transplant Cohort Study (STCS), using the American Educational Research Association framework. Methods Using a cross-sectional design, we enrolled a convenience sample of 926 home-dwelling kidney transplant recipients (median age, 59.69 years; 25%-75% quartile [Q25-Q75], 50.27-59.69), 63% men; median time since transplant 9.42 years (Q25-Q75, 4.93-15.85). Daytime sleepiness was assessed by using a single item from the STCS and the 8 items of the validated Epworth Sleepiness Scale. Receiver operating characteristic curve analysis was used to determine the cutoff for the STCS daytime sleepiness item against the Epworth Sleepiness Scale score. Results Based on the receiver operating characteristic curve analysis, a score greater than 4 on the STCS daytime sleepiness item is recommended to detect daytime sleepiness. Content validity was high as all expert reviews were unanimous. Concurrent validity was moderate (Spearman ρ, 0.531; P < .001) and convergent validity with depression and poor sleep quality although low, was significant (ρ, 0.235; P <.001 and ρ, 0.318, P =.002, respectively). For the group difference validity: kidney transplant recipients with moderate, severe, and extremely severe depressive symptom scores had 3.4, 4.3, and 5.9 times higher odds of having daytime sleepiness, respectively, as compared with recipients without depressive symptoms. Conclusion The accumulated evidence provided evidence for the validity of the STCS daytime sleepiness item as a simple screening scale for daytime sleepiness.

( Progress in Transplantation. 2013;23:xxx-xxx)

Year
2013
Type
Article
Authors
Burkhalter H. et al
Journal
no journal provided
URL
no url provided
2013 Validity of 2 sleep quality items to be used in a large cohort study of kindey transplant recipients
Abstract

Context Poor sleep quality and poor daytime functioning affect many kidney transplant patients.

Objective To evaluate the validity of 2 items assessing sleep quality and daytime functioning using the Pittsburgh Sleep Quality Index as reference standard before use in a large cohort study, following the American Psychological Associations guidelines.

Design A cross-sectional study using a psychosocial questionnaire developed for a large cohort study and the Pittsburgh Sleep Quality Index.

Sample and Setting One hundred thirty-five home-dwelling kidney transplant patients aged 21 to 76 years (mean, 51.6 years; SD, 11.9 years).

Main Outcome Measures Evidence on content, internal structure, and relation to other variables.

Results The Pittsburgh Sleep Quality Index indicated a 47.4% prevalence of poor sleep quality; the sleep quality item in the psychosocial questionnaire showed a 30.7% prevalence of poor sleep quality and a 34.1% prevalence of poor daytime functioning. Content validity was good for the psychosocial questionnaires sleep quality item but poor for its daytime functioning item. As hypothesized, the psychosocial questionnaires sleep quality item was moderately correlated with its daytime functioning item (Spearman rho, ρs = 0.520, P < .001), indicating related but distinct concepts. When combined, the 2 items from the psychosocial questionnaire showed significant correlations with the total score on the Pittsburgh Sleep Quality Index ( ρs = -0.784, P < .001), depressive symptoms ( ρs = -0.680, P < .001), perceived health status ( ρs =0.619, P <.001), and subjective health status ( ρs =0.671, P <.001) in the expected directions.

Conclusion For kidney transplant patients, validity is strong for the psychosocial questionnaires sleep quality item, but the mixed findings regarding the validity of the daytime functioning item suggest that additional items are needed to measure daytime functioning. ( Progress in Transplantation. 2011;21)

Year
2013
Type
Article
Authors
Burkhalter H. et al
Journal
no journal provided
URL
no url provided
2012 Relevance of cohort studies for the study of transplant infectious diseases
Abstract
no abstract provided
Year
2012
Type
Article
Authors
Christoph Berger, Katia Boggian, Alexia Cusini, Christian Van Delden, Christian Garzoni, Hans H Hirsch, Nina Khanna, Michael Koller, Oriol Manuel, Pascal Meylan, et al.
Journal
Current opinion in organ transplantation
URL
no url provided
2012 Squamous cell carcinoma of the skin induces considerable sustained cost of care in organ transplant recipients
Abstract
no abstract provided
Year
2012
Type
Article
Authors
Christian P Rüegg, Nicole Graf, Beda Mühleisen, Thomas D Szucs, Lars E French, Christian Surber, and Günther FL Hofbauer
Journal
Journal of the american academy of dermatology
URL
no url provided